Molecular Genetic Studies of Bone Mechanical Strain and of Pedigrees with Very High Bone Density
Abstract
Our past studies have revealed that the bone formation response to physical activity is genetically regulated. During this grant period, we have devised the means to study the genes responsible for this genetic regulation in in-bred strains of mice. These genes are of utmost importance because of their potential effects on all living humans. These studies in mice will be complimented by in vitro studies that have provided exciting information on the signaling pathways involved in the variable bone formation response to exercise. This type of information is essential to a full understanding of this important adaptive process. The second project is to perform genetic linkage analysis in a large pedigree with very high bone density, an analysis that could reveal genes important for providing diagnostic and treatment information. Phenotype and genotype data were collected and linkage analysis was performed by appropriate computer programs to locate two important loci for high bone density, chromosome 11 and chromosome 18. We are now engaged in fine mapping to identify the genes. The identity of the genes in these two loci could have important implications for our military with respect to susceptibility to battlefield injury and healing response to battlefield injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA416110
Entities
People
- David J. Baylink