Localization and Expression of the Proto-Oncoprotein BRX in the Mouse Brain and Pituitary
Abstract
A new member of the Dbl family of oncoproteins was discovered in breast cancer tissue extracts. This novel protein, designated Brx, contains an estrogen-receptor binding motif and is highly expressed in hormone-responsive breast tissue. Due to its ability to augment ligand-dependent activation of estrogen receptors, we analyzed the expression of Brx in the adult mouse brain and pituitary. Results indicated that Brx is expressed in specific regions of the brain and pituitary. Furthermore, the results indicate that differences exist in both brain and pituitary tissue of male and female mice with greater expression in the female. However, estrogen was not able to regulate Brx expression in ovariectomized mice. The anatomical studies support a role for Brx in its association with the estrogen receptor and that Brx may be involved in neuronal and pituitary function in a sexually dimorphic manner.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 13, 2003
- Accession Number
- ADA416449
Entities
People
- David O. Eddington
Organizations
- Uniformed Services University of the Health Sciences