Role of Chromatin Remodeling by RAD54 in DNA Damage Repair and Homologous Recombination

Abstract

Chromosomal double-strand breaks (DSBs) can arise from cellular DNA metabolism and from eogenous DNA-damaging agents. Efficient repair of these DSBs is critical for genome stability. Rad54, a member of the SWI2/SNF2 family, is involved in the homology recombination (ER) DNA repair pathway. Rad54 has been shown to physically associate with Rad51, a eukaryotic recombinase that in mammals interacts with tumor suppressors BRCA1 and BRCA2.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2003
Accession Number
ADA416619

Entities

People

  • Mariela Jaskelioff

Organizations

  • University of Massachusetts Medical School

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Biochemistry
  • Breast Cancer
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromosome Structures
  • Dynamics
  • Eukaryotes
  • Exchange Reactions
  • Free Energy
  • Genetics
  • Molecular Biology
  • Molecules
  • Neoplasms
  • Organic Chemistry
  • Sugar Alcohols

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Molecular Genetics

Technology Areas

  • Biotechnology