Hepatocyte Growth Factor and Interleukin-6 in Prostate Cancer Bone Metastasis

Abstract

Overview of tasks accomplished in the first year. In the first year of the award, we evaluated the design and progression of experiments of the project. We completed the first task, listed in the statement of work. In addition, I moved from Cornell University to the Fred Hutchinson Cancer Research Center. The environment at FHCRC is conducive to abroad genome wide analysis to determine the entire spectrum of androgen-regulated growth factors in bone, which is listed under task 4. As a first step, we analyzed the expression of hepatocyte growth factor (HGF) and interleukin-6 (IL-6) in mouse bone, which is part of task 1. We also evaluated changes in expression levels as a result of androgen deprivation of bone and bone marrow. The assay development and results are listed in detail in the following section.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2003
Accession Number
ADA416620

Entities

People

  • Beatrice S. Knudesen

Organizations

  • Weill Cornell Medicine

Tags

DTIC Thesaurus Topics

  • Androgens
  • Bone And Bones
  • Bone Marrow
  • Bone Marrow Cells
  • Cancer
  • Cells
  • Diseases And Disorders
  • Dna Microarrays
  • Epithelial Cells
  • Growth Factors
  • Metastasis
  • Neoplasms
  • New York
  • Osteoblasts
  • Peptide Growth Factors
  • Prostate
  • Proteins

Readers

  • Immunology and Pathology
  • Prostate Cancer Biology.
  • Technical Research and Report Writing.