Identification of a Receptor for Tumor Suppressor HIN-1
Abstract
The goal of this project is to identify a receptor for the putative HIN-l tumor suppressor gene. HIN-l is a secreted protein therefore it is likely to exert its effect on cells through binding to a cell surface protein: the HIN-1 receptor (HIN-1R). Thus, in order to understand the function of HIN-l we have to identify and characterize the HIN-1 receptor. This year we have made significant progress towards understanding the function of HIN-1 and the signaling pathways it may be involved in. Although the molecular identity of the HIN-l receptor is still unknown, we have excluded several candidate receptors and signaling pathways and characterized the biochemical properties of the putative HIN-1 R in further detail. Since the previously described expression cloning approach has not led to the identification of a HIN-1 receptor, we are trying additional approaches described here.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA416631
Entities
People
- Dale A. Porter
- Kornélia Polyák
Organizations
- Dana–Farber Cancer Institute