Molecular Determinants of Prostate Cancer Progression Across Race-Ethnicity

Abstract

This Prostate Cancer Center Initiation grant has been designed to identify genetic and molecular markers of prostate cancer progression within and between racial ethnic groups (African-Americans, Latinos, Whites, Japanese) at substantially distinct underlying risk of prostate cancer. Our Epidemiology Core has obtained signed tissue releases from prostate cancer patients to date identified during follow-up of the Hawaii/Los Angeles Multiethnic Cohort study and has procured 438 tissue samples to date (163 African-Americans, 163 Latinos, 74 Caucasians, and 38 Japanese). These have been processed histopathologically by Project C, which has completed immunohistochemical staining for COX-2, p27, and Caveolin-1 markers with analysis of additional markers ongoing. Project B, studying the androgen receptor (AR) gene in detail, has conducted functional studies to understand non-steroidal activation of AR signaling. Project A, studying the SRD5A2 gene in detail, has characterized a series of the somatic mutations identified in tumors to date using site directed mutagenesis assays.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2003
Accession Number
ADA416738

Entities

People

  • Brian E. Henderson
  • Gerhard A. Costzee
  • Juergen Reichardt
  • Ricahrd Cote
  • Ronald K. Ross

Organizations

  • University of Southern California

Tags

DTIC Thesaurus Topics

  • African Americans
  • Androgen Receptors
  • Androgens
  • Asian Americans
  • Biomedical Research
  • Caucasians
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Ethnic Groups
  • Genetics
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Prostate Cancer
  • Proteins
  • Tissues

Readers

  • Molecular and genetic basis of cancer.
  • Prostate Cancer Biology.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology