Molecular Basis for the Toxicity of Schweinfurthins to Breast Cancer Cells
Abstract
The schweinfurthins are a small set of diprenylated stilbenes isolated from an African plant. Schweinfurthins A, B, display significant and unique activity in the NCI's 60 cell line panel, and the breast cancer lines MCF7 and HS 578T were among the most sensitive. To study the mechanism of action and provide a reliable source, a chemical synthesis has been initiated. Two similar cationic cyclization routes have been explored one of which holds promise of giving enantiopure material. The very advanced compound 3-deoxyschweinfurthin B has been synthesized in enantioenriched form and is currently undergoing bioassay at the NCI. This compound demonstrates the viability of our over synthetic strategy and will give valuable information pertaining to the chemical nature of the activity in these compounds.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA416777
Entities
People
- David Wiemer
- Jeffrey D. Neighbors
Organizations
- University of Iowa