Role of Alpha(v)Beta(3) Integrin in the Establishment and Growth of Metastatic Lesions in Prostate Cancer
Abstract
Significant controversies exist on which therapy constitutes the optimal treatment for prostate cancer. A better understanding of the biologic mechanisms responsible for the uncontrolled growth and motility of prostate cancer cells is critical to devise novel therapeutic approaches. Considerable interest has recently focused on the role of integrins as signal transducing molecules that ultimately control cell invasion, metastasis, and proliferation. The area of research that focuses on the role of integrins in the modulation of prostate cell metastatic establishment and growth is "under-investigated", whereas a significant progress has been made on breast cancer in this field. The studies, nonetheless, are important because integrins, specifically the Beta 3 integrin, play a role in cancer cell proliferation, tumor growth, invasion, and metastatic spread.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2002
- Accession Number
- ADA416781
Entities
People
- Thomas D. Manes
Organizations
- Yale University