Signal Transduction in Prostate Cancer
Abstract
The goal of this Prostate Cancer Center Initiation Award was to examine signal transduction pathways involved in prostate cancer progression, with an eye toward translational research applications. The program had two Projects and a Core Animal Facility. The first project (Dr. Carey) focused on crosstalk between receptor tyrosine kinases and the androgen receptor (AR), using the Her2/neu kinase as a model system. During the funding period we completed preclinical studies with an EGFR/Her2-neu kinase inhibitor with new, unexpected insights about the clinical application of these drugs. We have also defined some of the molecular details of AR/Her2 crosstalk. Finally we developed imaging technologies to follow disease progression in mouse models. The second project (Dr. Cohen) examined the role of IGF binding protein 3 (IGFBP-3) in the context of crosstalk with the retinoic acid co-receptor RXR(alpha). We confirmed that IGFBP-3 induces apoptosis in synergistic fashion with RXR(alpha) ligands in multiple prostate models, using the Core facility. Both projects led to the conception of clinical translational projects hat are components of the recently funded UCLA Prostate SPORE grant.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2003
- Accession Number
- ADA416805
Entities
People
- Charles Sawyers
Organizations
- University of California, Los Angeles