Preeclampsia-Associated Hormonal Profiles and Reduced Breast Cancer Risk Among Older Mothers
Abstract
Preeclampsia has been linked to reduced breast cancer risk, and this reduction may be especially marked among women who bear their first child later in life. In this ongoing case-control study, we examine the hormonal profiles of older Colorado mothers with and without a history of preeclampsia in their first pregnancies. Subjects are nonpregnant, non-smoking women who completed their first pregnancies at age 30 or older, are currently premenopausal, and are free of serious chronic disease. Cases are 14 Denver area women who experienced preeclampsia in their first pregnancy; controls are 13 women with uncomplicated first pregnancies, frequency matched to cases on race/ethnicity, current age, age at delivery, and breast-feeding status. A fasting blood and saliva sample was collected from each subject during the luteal phase (day 19-22) of the menstrual cycle and assayed for specific steroid and peptide hormones thought to be linked to breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2003
- Accession Number
- ADA416868
Entities
People
- Mark L. Laudenslager
Organizations
- University of Colorado Boulder