Genetic and Epigenetic Mechanisms Underlying Acute and Delayed Neurodegenerative Consequences of Stress and Anticholinesterase Exposure
Abstract
We have observed the role of the stress-associated acetylcholinesterase variant, AChE-R in several model systems. In AChE transgenic mice, the neuronal overexpression of AChE-R is associated with behavioral impairments. In another animal model, the honey bee, developmental reduction of ache gene expression paralleled their normal, consistent improvement of behavioral functions, and experimental improvement under mild rivastigmine exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2001
- Accession Number
- ADA416887
Entities
People
- Hermona Soreq
Organizations
- Hebrew University of Jerusalem