Diet Genetic Polymorphisms and Breast Cancer in African-Americans
Abstract
Dietary fat and cooking practices, such as overcooking of meats that can lead to the formation of heterocyclic amines (HAAs) and polycyclic aromatics hydrocarbons (PAHs), differ by racial groups and culture. The project is a case control study designed to assess the role of dietary fat, cholesterol, cooking practices (e.g., of fatty foods that would increase HAAs and PAHs), smoking, and alcohol consumption as risk factors for breast cancer among African-American women in Washington, DC. The primary goal of the project is to identify non-hormonal dietary risk and genetic susceptibility factors for breast cancer in African-American women. To date, a total of 9% breast cancer cases and 96 controls have completed the study. The conditional response rate is 44% for cases and 13% for controls. The refusal rate is 11% for cases and 10% for controls. Preliminary analysis has revealed that in this sample of African-American women there is a dose response relationship between alcohol use and breast cancer risk. In addition, genotype analysis of NAT has revealed consistent findings with current literature. The African-American women were more often slow acetylators than rapid or intermediate. Mutagen sensitivity suggests an association between chromosomal radiosensitivity and risk of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2002
- Accession Number
- ADA416961
Entities
People
- Lucille L. Adams-campbell
Organizations
- Howard University