Therapy of Experimental Nerve Sheath Tumors Using Oncolytic Viruses

Abstract

Peripheral nerve sheath tumors are the major tumors in neurofibromatosis type 1 (NF1). Malignant transformation of these tumors leads to extremely poor prognosis without therapy. The main goal of this project is to determine the efficacy of recombinant oncolytic herpes simplex type 1 viruses (HSV) for the therapy of nerve sheath tumors. To that aim we will generate reliable tumor models for malignant peripheral nerve sheath tumors (MPNST). Several existing oncolytic HSV will then be tested on these models for therapeutic utility. In addition, oncolytic therapy will be combined with experimental antiangiogenic therapy.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA417108

Entities

People

  • Andreas Kurtz

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Blood Coagulation Factors
  • Blood Vessels
  • Cell Line
  • Cells
  • Fibroblasts
  • Health Services
  • Infection
  • Inhibitors
  • Nervous System
  • Neuromuscular Diseases
  • Oncolytic Viruses
  • Peripheral Nervous System
  • Proteins
  • Therapy
  • Viruses

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and Cellular Biology
  • Virology (or Medical Virology).