Coactivators and Corepressors in Breast Development and Receptor-Dependent Tumorigenesis
Abstract
Estrogens are important regulators of growth and differentiation in the normal mammary gland and are also important in the development and progression of breast carcinoma. Estrogens regulate gene expression via estrogen receptor (ER) protein and, because approximately two-thirds of all breast cancers are ER+ at the time of diagnosis, the expression of the receptor has important implications for their biology and therapy. ER binds to the estrogen response element (ERE) found in the promoters of estrogen- regulated genes and activates their transcription. Several cofactors (coactivators and corepressors) have been identified that are of importance in regulating the ER interaction with the basal transcription machinery. Herein, we will address the role of specific cofactors in ER action and the rules that govern the specific recruitment of these proteins to specific promoters.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA417426
Entities
People
- Ivan G. Bassets
- Soo-kyung Lee
Organizations
- University of California, San Diego