Impact of Polychlorinated Biphenyl Congener 126 (PCB 126) on the Immune Function of Aged and Juvenile Japanese Medaka (Oryzias latipes)

Abstract

Polychlorinated biphenyls (PCBs) exist today as a major contaminant in water resources worldwide. Produced in the United States under the trade name Aroclor, PCBs were synthesized for use as insulating fluids, plasticizers, and various industrial applications (Swain, 1983; Safe et al., 1987). Since their recognition as an environmental hazard in the 1960's, PCB production in the U.S. ceased in the late 1970's. Nevertheless, PCBs continue to persist in the environment due to their high lipid solubility and, subsequently, bioaccumulate throughout the food chain. This study identifies both host age and post-exposure duration as factors influencing the impact of PCB 126 on the fish immune system. The results demonstrate that the Japanese medaka is a sensitive laboratory model for determining PCB-induced immunodysfunction.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2001
Accession Number
ADA417490

Entities

People

  • Jessica E. Duffy

Organizations

  • NYU Langone Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aromatic Hydrocarbons
  • Birds
  • Cells
  • Chemistry
  • Ecotoxicology
  • Environment
  • Environmental Health
  • Fish
  • Fisheries
  • Immune System
  • Polychlorinated Biphenyls
  • Rodents

Fields of Study

  • Environmental science

Readers

  • Aquatic Ecology

Technology Areas

  • Microelectronics