Prospective Evaluation of Hormone Replacement Therapy, Body Mass Index, Estrogen Metabolism and Breast Cancer Risk

Abstract

The objective of this project is to prospectively evaluate the extent to which BMI and estrogen metabolism are related to breast cancer associated with HRT use. We will specifically test the following hypotheses: Among postmenopausal women using HRT: a). the risk of breast cancer is higher for women with higher serum 16-OH levels b). lower BMI is associated with higher serum 16-OH levels c). therefore: the risk of breast cancer increases with decreasing BMI We will also test the relationship between serum 2-OH levels, the 2:16-OH ratio, BMI and breast cancer risk. This will be done using a nested case/control study within the observational arm of the Womens Health initiative.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA417504

Entities

People

  • Francesmary Modugno

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Drug Therapy
  • Electronic Mail
  • Epidemiology
  • Estrogens
  • Health
  • Hormones
  • Hypotheses
  • Menopause
  • Metabolism
  • Neoplasms
  • Progesterone
  • Sex Glands
  • Test And Evaluation
  • Therapy

Fields of Study

  • Medicine

Readers

  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.