Molecular Mechanisms of Breast Cancer Metastasis

Abstract

Metastasis accounts for the majority of deaths associated with breast cancer. There is a need to identify prognostic/predictive indicators to accurately determine whether breast cancer cells are likely to metastasize. Hp1(Hs alpha) (Heterochromatin Protein 1) has been identified as a candidate breast cancer metastasis suppressor that is down-regulated in highly invasive/metastatic breast cancer cells compared to poorly invasive/non-metastatic cells. HP1(Hs alpha) is a non-histone chromosome protein that plays a role in chromosome segregation, chromatin packaging, and gene silencing.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2003
Accession Number
ADA417529

Entities

People

  • Lori L. Wallrath

Organizations

  • University of Iowa

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Nucleus Structures
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chromosome Structures
  • Chromosomes
  • Gene Expression
  • Genetics
  • Metastasis
  • Neoplasms
  • Proteins
  • Transcription Factors

Readers

  • Molecular Biology and Genetics
  • Oncology and Biomarker-Based Cancer Detection.