HOXB7: An Oncogenic Gene in Breast Cancer Cells?
Abstract
Homeobox genes control anterioposterior body axis patterning during development. Although expressed primarily in developing embryos, a growing body of evidence shows that homeobox gene re-expression in adult tissues is associated with tumorigenesis. Earlier work has shown that introduction of HOXB7, one of the members of this gene family, into non-expressing breast cancer cells induced expression of a number of pro-angiogenic factors and formed tumors upon xenograft into nude mice. We had earlier identified HOXB7 as an overexpressed gene in a SAGE analysis of breast cancer cell lines and wanted to investigate its oncogenic potential in this study.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA417673
Entities
People
- Ethel Rubin
- Saraswati Sukumar
Organizations
- Johns Hopkins University