Effects of Nationally-Occurring Estrogen-Fatty Acid Esters on Mammary Cell Growth and Carcinogenesis in Female Rats
Abstract
My studies have compared the carcinogenic effects of an E(2)-17 beta-fatty acid ester preparation, E(2) and 4-OH-E(2) in the breast, pituitary and uterus of ACI rats. Results showed that chronic administration of an E(2)-17 beta-fatty acid ester preparation to these rats preferentially induces the development of mammary tumors while chronic administration of E(2) results in the preferential formation of pituitary tumors. The chronic administration of 4-OH-E(2) to intact female ACI rats did not induce the formation of mammary or pituitary tumors, although there was hyperplasia present in the mammary glands. These results are the first report demonstrating that chronic administration of an estrogen fatty acid ester selectively induces the development of mammary tumors in this animal model. In order to study the carcinogenic activity of other estrogen fatty acid esters, such as those of 4-OH-E(2), they must first be synthesized.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA417683
Entities
People
- Bao T. Zhu
- Laura H. Mills
Organizations
- University of South Carolina