Definition of the Molecular Mechanisms Which Distinguish Between Selective Estrogen Receptor Modulators (SERMs) and Full Antiestrogens

Abstract

Tamoxifen, a SERM (Selective Estrogen Receptor Modulator), is the most commonly used endocrine treatment for all stages of breast cancer. However, progression from tamoxifen sensitivity to tamoxifen resistance occurs in a substantial portion of the tumors. Full antiestrogens, such as ICI 182,780, are currently used as the second line therapy after failure of long-term tamoxifen therapy. To facilitate the design and characterization of more appropriate therapeutic agents for endocrine therapy of breast cancer, it is very important to understand the functional mechanisms that distinguish full antiestrogens from SERMs.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2003
Accession Number
ADA417684

Entities

People

  • Huey-jing Huang

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Amino Acids
  • Biomedical Research
  • Biomolecules
  • Breast Cancer
  • Chemical Compounds
  • Dna Sequence Analysis
  • Estrogens
  • Hormone Antagonists
  • Hormones
  • Modulators
  • Mutations
  • Neoplasms
  • North Carolina
  • Proteins
  • Resistance
  • Sequences

Readers

  • Breast cancer cell signaling and growth regulation.