Characterization of the Interaction of BRCA1 and Protein Phosphatase 1

Abstract

The breast cancer susceptibility gene BRCA1 is mutated in many cases of familial breast and ovarian cancer. BRCA1 plays a role in DNA repair, centrosomal function, ubiouitination, and the transactivation of genes. The phosphorylation status of BRCA1 changes throughout the cell cycle, and upon DNA damage. Phosphorylation may, therefore, play an important role in the regulation of BRCA1 function.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2003
Accession Number
ADA417685

Entities

People

  • Sherry L. Hendry

Organizations

  • Mount Sinai Hospital, Toronto

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Cytoskeleton
  • Health Services
  • Identification
  • Neoplasms
  • Neutral Amino Acids
  • Ovarian Cancer
  • Phosphorylation
  • Proteins
  • Regulations

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology