Characterization of SIRPs in Prostate Cancer Cells
Abstract
Signal regulatory proteins (SIRPs) include SIRP beta 1%, which activates cells, and SIRP alpha 1, which inhibits the cellular response to several growth factors, and which regulates cell adhesion and spreading. We demonstrated by PCR that 3 of 3 prostate cancer cell lines (PC-3, DU-145 and LNCaP) express transcripts for SIRPs. Under this contract, we generated a monoclonal antibody that recognizes both SIRP beta 1 and SIRP alpha 1, thereby confirming the expression of SIRPs on PC-3 cells and, to a lesser extent on DU-145 cells. The receptor could not be detected on cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2003
- Accession Number
- ADA417693
Entities
People
- William E. Seaman
Organizations
- Northern California Institute for Research and Education