Designing Rugged Single Molecule Detectors for Stochastic Sensing: A Biological Surface Science Approach
Abstract
This project involved the use of supported phospholipid bilayers to design a new generation of highly rugged single molecule sensors devices. The devices employed alpha-hemolysin, a pore forming protein, as a single molecule transducer element. Our studies demonstrated that this ion channel could be inserted into supported bilayers while retaining two-dimensional mobility. Furthermore, we designed a variety of microfluidic and array-based platforms with concentration and temperature control for displaying this stochastic sensor element.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 19, 2003
- Accession Number
- ADA417745
Entities
People
- Paul S Cremer
Organizations
- Texas A&M University