Comprehensive Development Program of Hunter-Killer Peptides for Prostate Cancer

Abstract

13. ABSTRACT (Maximum 200 Words) Prostate cancer is now the most common cancer among men in the United States. Angiogenesis is required for prostate tumor survival, growth, and metastasis. We proposed to design novel Hunter-Killer Peptides (HKPs), each representing a chimeric peptide of an angiogenesis-targeting peptide and a mitochondrial membrane-disrupting peptide. While non-toxic in the circulation, the HKPs will be preferentially toxic to mitochondria once internalized into angiogenic cells, via the targeting domain.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2003
Accession Number
ADA417782

Entities

People

  • Howard M. Ellerby

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Blood
  • Blood Vessels
  • Breast Cancer
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Medical Personnel
  • Mitochondria
  • Peptides
  • Proteins
  • Therapy

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).