Computational Modeling of the Prostate-Expressed Lysophosphatidic Acid Receptor Edg-7
Abstract
Recently it was shown that the lysophosphatidic acid (LPA) receptor LPA3/EDG7 is expressed in human prostate cancer cell lines namely LNCap and Du-145. Based on these findings and evidence that LPA is a very potent mitogen, the overall goal of this proposed research is to rationally design LPA3/EDG7 selective ligands. We have identified the probable binding position of two LPA1/EDG2 and LPA3/EDG7 selective inhibitors namely DGPP (8:0) and FAP (12:0). The binding position and the critical amino acids involved in interacting with these inhibitors relative to the endogenous ligand LPA (18:1) is discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2003
- Accession Number
- ADA417853
Entities
People
- Abby L. Parrill
- Vineet M. Sardar
Organizations
- University of Memphis