Interrelationships of Prenatal and Postnatal Growth, Hormones, Diet, and Breast Cancer
Abstract
The purpose of this Career Development Award was to expand Dr. Sanderson's current breast cancer research from the effect of intrauterine exposure to estrogen on breast cancer to the interrelationships of prenatal and postnatal growth, hormones, diet and breast cancer. Based on these interrelationships, we hypothesized that insulin resistance will be positively associated with breast cancer. Further, we hypothesized that genetic susceptibility, and adolescent/adult diet and physical activity will modify the effect of insulin resistance on breast cancer. Specific aims were: 1) to undergo intensive training in cancer biology, and nutritional, molecular and genetic epidemiology, 2) to obtain finding to conduct case-control studies of the insulin resistance-breast cancer relationship, and 3) to obtain finding to conduct a cohort study of the association between prenatal and postnatal growth and infant hormone levels. During the third year of the study, Dr. Sanderson helped develop a course in Nutritional Epidemiology, conducted analyses of dietary intake, anthropometric measurements and insulin-like growth factor I from the Shanghai Breast Cancer Study, submitted a proposal for a HBCU/MI Partnership Award to the Department of Defense to investigate insulin resistance and breast cancer, and participated in the Lower Rio Grande Valley Nutrition Intervention Research Initiative consortium.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA417878
Entities
People
- Maureen Sanderson
Organizations
- University of South Carolina