P38 Mitogen-Activated Protein Kinase in Metastasis Associated With Transforming Growth Factor Beta

Abstract

Metastatic breast cancer cells express high levels of the transforming growth factor!beta (TGFbeta). Although TGFbeta is a potent tumor suppressor, it can promote formation of highly metastatic tumors by stimulating an epithelial to mesenchymal transition (EMT), cell migration, and changes in tumor microenvironment. Our initial observation indicated that p38 mitogen activated protein kinase (p38Mapk) is required for these TGFbeta responses in epithelial cells. Metastatic breast cancer cells express high levels of active p38Mapk and this contributes to tumor invasiveness. Thus, p38Mapk is a potential target for selective therapeutic intervention.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA417915

Entities

People

  • Andrei V. Bakin

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cytoskeleton
  • Epithelial Cells
  • Health Services
  • Intercellular Junctions
  • Medical Personnel
  • Peptide Growth Factors

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics