Aging, Breast Cancer, and the Mouse Model
Abstract
Cancer incidence rises exponentially with age. We have previously shown that human senescent cells stimulate the proliferation of premalignant and malignant breast epithelial cells in culture. Senescent cells exist and accumulate with age in vivo, suggesting that senescence might contribute to the increase of breast cancer with age. This project test the hypothesis that senescent mouse fibroblasts also stimulate epithelial growth by creating a permissive environment for the expression of epithelial malignancies.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA417918
Entities
People
- Judith Campisi
- Simona Parrinello
Organizations
- Lawrence Livermore National Laboratory