Mechanism of Ultrashort Pulse Laser Injury to the RPE (Retinal Pigment Epithelium)

Abstract

Previous studies in our laboratory have established that microbubble formation inside the RPE cells is the damage mechanism for single exposures of short laser pulses from 100 fsec to -1 micro sec. In the current project, we investigated the mechanism for multiple laser pulse injury to RPE cells using a new pump-probe setup. We also investigated the expression of heat shock proteins as potential a marker of sublethal injury following short pulse laser exposure. Finally, we developed a slitlamp based light scattering system for monitoring laser-induced bubble formation in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Feb 14, 2003
Accession Number
ADA417926

Entities

People

  • Charles P. Lin

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Pigments
  • Cell Physiological Processes
  • Cells
  • Detection
  • Detectors
  • Electromagnetic Radiation
  • Electromagnetic Scattering
  • Epithelium
  • Health Services
  • Laser Beams
  • Laser Pulses
  • Laser Safety
  • Lasers
  • Light Scattering
  • Optical Properties
  • Radiation
  • Scattering

Fields of Study

  • Physics

Readers

  • Optical Physics and Photonics.
  • Vision Science/Vision Psychology/Cognitive Neuroscience.

Technology Areas

  • Directed Energy