Potentiation of T Lymphocyte Responses by Modulating NF - Kappa Beta Activity in Dendritic Cells
Abstract
The goal of this investigation is to determine whether modulation of NF-KB activity by genetic engineering of DCs can affect DC longevity and T cell stimulatory functions. The specific aims are: 1) To determine the effect of expression of constitutively-active IKKBeta IkE kinase) on nuclear NF-kB levels in DCs, and on the longevity of DCs. 2) To determine the effect of IKKbeta expression on in vitro and in vivo T cell priming by DCs. Results from these studies may thus lead the way for development of approaches for enhancing DC survival and function, with the goal of generating potent anti-tumor immunity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA417929
Entities
People
- Amer A. Beg
Organizations
- Columbia University