Overcoming Resistance of Prostate Cancer to TRAIL-Mediated Apoptosis

Abstract

TRAIL-TNF-related apoptosis inducing ligand) is a protein that induces apoptotic cell death in cancerous but not normal tissues. TRAIL has the potential to be a novel prostate cancer treatment. However, we have found that the majority of prostate cancer cell lines are insensitive to this agent. The goal of this proposal is decipher the nature of this resistance and develop biochemical tools to enhance the sensitivity of prostate cancer to TRAIL killing. Scope This proposal examines normal prostate epithelia, prostate cancer cell lines, and animal tumors for sensitivity to TRAIL.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA417935

Entities

People

  • Andrew S Kraft

Organizations

  • University of Colorado Health

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Apoptosis
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Enzyme Inhibitors
  • Epithelial Cells
  • Fungi
  • Indicator Dyes
  • Molecules
  • Neoplasms
  • Programmed Cell Death
  • Proteins
  • Resistance
  • Tissues
  • Tumor Cell Line

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and genetic basis of cancer.