SEEDling Grant to Establish Pilot Data for a Consortium on Magnetic Nanoparticle Assemblies: A New Tool for Drug Delivery, Sensors and Electronic Devices
Abstract
This project has entailed the development of magnetic materials with potential suitability as vehicles for magnetic field-directed drug delivery, and the design and implementation of a laboratory-scale instrument for measuring the magnetophoretic behavior of new materials in flowing media. Triblock copolymers comprised of hydrophilic poly(ethylene oxide) tail blocks and a polyurethane anchor block containing carboxylic acid binding groups were designed and synthesized. A method for preparing stabilized dispersions of magnetite nanoparticles coated with the stabilizers was developed, and these coated nanoparticles could be dispersed in water. Dispersions of the particle-copolymer complexes remained stable (did not separate) when these materials were dialyzed rigorously and subjected to repeated centrifugation steps to eliminate potentially toxic extractables. An in-vitro assay of toxicity was developed to assess cell survival in the presence of the magnetite nanoparticle-copolymer complexes. A first generation magnet system was designed in collaboration with our colleagues at Stereotaxis (St. Louis, MO). This research scale magnetic guidance system is now in place at VA Tech.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2003
- Accession Number
- ADA417938
Entities
People
- Judy S Riffle
- Richard O. Claus
- Urs Hafeli
Organizations
- Virginia Tech