Genetic Alteration of Metabolism and Tumorigenicity of Prostate Cancer Cells
Abstract
In the prostate, overwhelming evidence now exists that zinc and citrate metabolism are important factors in the pathogenesis and progression of prostate cancer (Pca). This proposal is aiming to establish that the pro static tumor cells obtained from PC-3 and LNCaP-derived tumors are citrate oxidizing cells; and to demonstrate that the genetic alteration of zinc accumulation and expression of m-aconitase will alter citrate oxidation and will correspondingly alter the tumorigenic capabilities of LNCaP and PC-3 cells. The second year study was focused on: 1) to study the zinc effect on the prostate tumorigenicity in vivo; 2) to establish and characterize ZIP1 over-expressed PC-3 cells; 3) To determine the tumorigenic capacity of ZIP1 over-expressed PC-3 cells; 4) To establish ZIP1 over-expressed LNCaP cells using stable transfection technique. At the present time the progress of this study is very promising, and we anticipate continuation of significant outcomes from this project. With this grant support, two abstracts were published and presented in international and local meetings, one paper was published and two manuscripts have been submitted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA417940
Entities
People
- Pei Feng
Organizations
- University of Maryland, Baltimore