A Large Scale Genomic Approach to Prostate Cancer Risk in African American Men
Abstract
We are using a haplotype based approach to understand how genetic variation in the GH/IGF- 1 pathway affects prostate cancer risk in African-American men. The sequencing of the - - human genome along with the characterization and cataloguing of single nucleotide polymorphisms (SNPs) provides the raw material to understand how genotypic variation translates into phenotypic variation including disease risk. While prostate cancer is known to have a substantial genetic contribution to risk, progress has been slow in identifying the genes involved in the disease. By testing a large population in an association study design, we are powered to detect the modest risks that may be involved in this disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA417954
Entities
People
- Matthew L Freedman
Organizations
- Massachusetts General Hospital