A Novel Prostate Epithelium-Specific Transcription Factor in Prostate Cancer
Abstract
Our goal is to understand the role of a novel epithelium-specific Ets transcription factor, PDEF, in prostate cancer% Our progress over the last year has provided significant further evidence that PDBF is an important player in prostate and breast cancer. We were able to characterize the mouse PDEF gene and promoter and to generate knockout constructs for PDEF. We, furthermore, demonstrated that PDEF is a target for kinases in the MAP kinase pathway. We also identified a variety of target genes for PDBF related to adhesion, migration and cell cycle using transcriptional profiling, real time PCR and siRNA interference which will further help us to understand the biological function of PDEF. Our results as well as the critical roles of other Ets factors in cellular differentiation and tumorigenesis strongly suggest that PDBF is an important regulator of prostate gland development and plays a role in prostate and breast cancer progression or development. The new data have further strengthened our belief that PDEF is a prime target for drug development.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA417956
Entities
People
- Towie A. Liberman