Molecular Dissection of the S Phase Transcriptional Program Controlled by Cyclin E/P220 NPAT Signaling Pathway
Abstract
Cancer is fundamentally a disease of inappropriate cell division. Progression through the manunalian cell division cycle is controlled by cyclin dependent kinases (cdks) and their regulatory subunits, the cyclins. Entry of cells into S-phase depends upon the activities of cyclin D/cdk4 and cyclin E/cdk2 complexes. During the last few years, it has become clear that deregulation of the cyclin E pathway is associated with breast cancer (1). Although much is known about how cyclin E/cdk2 is regulated, relatively little is known about how it controls S-phase events, especially when its activity is deregulated. My work is focused on understanding how cyclin E controls S-phase events through its interaction with a novel protein, p220(NPAT).
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2003
- Accession Number
- ADA417961
Entities
People
- Jeffrey Harper
- Yue Wei
Organizations
- Baylor College of Medicine