Interactions Among Brca1, Brca2, and Components of the Recombination Machinery
Abstract
Homologous recombination (HR) is an important tool for the repair of chromosomes damaged by various mutagenic chemicals including alkylating agents and DNA cross-linking agents, and by ionizing radiation that causes DNA double strand breaks. The dozen or so of genes and proteins that function in concert to mediate homologous recombination are collectively known as the RAD52 epistasis group. In mammals, the breast tumor suppressors BRCA1 and BRCA2 regulate the efficiency of the HR machinery. Specifically, BRCAl binds the Rad50/Mrel1/Nbsl complex and BRCA2 interacts with the Rad51 protein.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA417993
Entities
People
- Patrick M. Sung
Organizations
- University of Texas Health Science Center at San Antonio