The Role of AKT2 in Human Breast Cancer

Abstract

Accumulated evidences showed that Akt is a major cell survival pathway and plays an important role in malignant transformation and chemoresistance. However, the underlying mechanisms have not been well documented. We demonstrated that Akt protects stress-induced programmed cell death by inhibition of stress kinase JNK/p38 through activation of NFkB pathway. Further, we have shown that human cancer cells expressing constitutively active AKT2 resist to cisplatin through inhibition of cisplatin-induced ASK1 (apoptosis signal-regulating kinase 1) activation. AKT2 phosphorylation of ASK1 led to abrogation of cisplatin-induced JNK/p38 activation and Bax conformational changes. MST1, one member of STE20 like kinase, has been shown to induce apoptosis through its cleavage, activation and nuclear translocation. We have recently observed that AKT2 inhibits MST1-induced apoptosis by phosphorylatiion of MST1 at Thr-120.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA417995

Entities

People

  • Jin Q. Cheng
  • Zeng-qiang Yuan

Organizations

  • University of South Florida

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Fibroblasts
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors
  • Programmed Cell Death
  • Proteins
  • Students

Fields of Study

  • Biology
  • Chemistry

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.