Integrin-Mediated Stimulation of HIF-1x and Angiogenesis in Breast Cancer
Abstract
Understanding the mechanisms involved in the progression from carcinoma in situ to metastatic disease is one of the most important problems in breast cancer research. To this end, studies by our group and others have implicated a critical role for the alpha6 integrins in breast cancer progression. For this reason, it is essential to elucidate the mechanisms by which these integrins contribute to breast cancer progression. This IDEA Award is based on the hypothesis that the alpha6 integrins regulate expression of VEGF, a growth factor that is essential for tumor survival and angiogenesis. In Year 2 of this Award, we have made considerable progress in validating this hypothesis and we have established that the alpha6betal integrin is necessary for the activation of HiF-lalpha, a transcription factor that regulates VEGF expression in breast carcinoma cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA418002
Entities
People
- Arthur M Mercurio
Organizations
- Beth Israel Deaconess Medical Center