Molecular Characteristics of Multicorn, A New Large Proteolytic Assembly and Potential Anti-Cancer Drug Target, in Human Breast Cancer Cells
Abstract
We have discovered a new giant proteolytic complex distinct from the proteasome and ubiquitous among Eukaryotes. The enzyme named multicom apparently takes part in the cell cycle regulation and is involved in partial overcoming the physiological effects of proteasome inhibitors. As the most significant accomplishment, we wish to report here the development and successful testing of AAF-CMAC, an in vivo fluorescent probe of peptidolytic activity of multicom.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA418003
Entities
People
- Maria Gaczyńska
Organizations
- University of Texas Health Science Center at San Antonio