Sprouty-1, An Inhibitor of Prostate Cancer Signal Transduction
Abstract
There is abundant evidence that increased expression of growth factors and increased activity growth factor receptors, particularly those of the fibroblast growth factor (FGF) and epidermal growth factor (EGF) families, play an important role in human prostate cancer. The sprouty gene was originally identified as a negative regulator of FGF and EGF receptor signaling in Drosophila. We have found that sprouty-1 is the major human sprouty homologue expressed in human prostate and it is significantly downregulated in approximately 70% of extensive, clinically localized prostate cancers. Our studies have indicated that this is due, at least in part, to altered transcriptional regulation of the sprouty- 1 gene in prostate cancer cells. Loss of this negative regulator of growth factor signaling may enhance tumor aggressiveness and be correlated with clinical, pathological and biological parameters of aggressive clinical behavior in human prostate cancer. We have now shown that expression of sprouty-1 in human prostate cancer cells, either by stable transfection or by expression via replication deficient adenovirus, markedly inhibits proliferation of prostate cancer cell lines. Studies to evaluate the prognostic significance of loss of sprouty-1 expression are currently underway.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418011
Entities
People
- Michael M. Ittmann
Organizations
- Baylor College of Medicine