Quantitative Characterization of Pulmonary Pressure-Volume Curve for Improved Care of Acute Lung Injury
Abstract
Based on the analyses of over seventy existing pressure- volume (pV) curves, continuous (tangent-hyperbolic or error function) pV model equations are confirmed to represent clinical pV curves accurately and also quantify differences and similarities among various p-V data sets effectively. A mechanistic model of the total respiratory system (TRS) is constructed, based on the principle of statistical mechanics applied to TRS as an ensemble of a large number of elements, each consisting of a piston-spring subsystem. The mechanistic model of the inflation process relates characteristics of the p-V model equation to the internal respiratory conditions such as an extent to which alveoli are recruited and the wall tissues are distended as pressure is increased. The model also computationally simulates an ideal deflation process, in which the volume decrease is solely due to the tissue contraction with the differences between a measured deflation curve and the corresponding ideal deflation curve representing the effects of airway closure and collapse on the deflation process.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA418013
Entities
People
- Uichiro Narusawa
Organizations
- Northeastern University