Estimation of Tumor Angiogenesis With Constrast Enhanced Subharmonic Ultrasound Imaging
Abstract
New contrast-specific imaging modalities such as harmonic imaging (HI) may improve the accuracy of breast ultrasound. Unfortunately, HI suffers form reduced blood-to-tissue contrast resulting form second harmonic generation and accumulation in tissue. As an alternative we propose using subharmonic imaging (SHI) by transmitting at the double the resonance frequency (2f sub o) and receiving at the subharmonic (f sub o). SHI has the potential to detect slow, small volume blood flow associated with tumor neovascularity, making early detection and identification of tumors very likely. Hence, the current project proposes to increase the ability of breast ultrasound to differentiate between denign and malignant lesions by combining injection of an ultrasound contrast agent with SHI. To date, in vitro experiments comparing SHI to flow rates have been completed showing good correlation with contrast uptake slopes. Animal experiments with rabbits were abandoned due to problems associated with the perfusion measurements. A new protocol using dogs was approved by the TJU IACUC. Two new interations of SHI software have been developed for a new scanning platform (the Logiq 9) and initial testing has commenced (in a canine model). A probe (the 7L) was selected for human studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418021
Entities
People
- Fleming Forsberg
Organizations
- Thomas Jefferson University