Laminin-10 and Its Receptors in Breast Carcinoma: Cooperation of Alpha6Beta4 and Alpha3Beta1 Integrin Laminin Receptors in Breast Carcinoma
Abstract
Insulin receptor substrate 1 and 2 are downstream signaling molecules for growth factors and adhesion receptors that are implicated in breast cancer. In this report, the author dissects the individual roles of IRS-1 and IRS-2 in the promotion and progression of breast carcinoma. The results show that IRS-1 and IRS-2 play distinct roles in the malignant progression of breast carcinoma. IRS-1 and IRS-2 are both required for cell proliferation, with IRS-2 being a better mediator of cell proliferation. The results also show that IRS-2, but not IRS-1, is required for cell survival in the absence of exogenous growth factors and in invasion. In fact, IRS-1 function might reduce the efficacy of IRS-2 in these processes. Altogether, the findings suggest that IRS-1 is involved in the early stages of breast cancer establishment and that IRS-2 is required for its maintenance and progression to malignancy. (6 figures, 20 refs.)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA418060
Entities
People
- Rana A. Awwad
Organizations
- Beth Israel Deaconess Medical Center