Interleukin-6 and Prostate Cancer Progression
Abstract
Prostate carcinoma (PCA) initially responds to androgen deprivation. However, it usually reoccurs in a form that is unresponsive to further hormonal manipulations. This latter form of PCA, termed androgen independent cancer, inexorably progresses resulting in the demise of the patient. Interleukin-6 (IL-6) and IL-6 receptor are expressed in PCA and activates the androgen receptor (AR) . In the current work we explored the hypothesis that IL-6 contributes to the progression of PCA that is observed post-androgen deprivation, through enhancing AR activity. We determined that blocking IL-6 diminishes development and progression of androgen-independent human PCA in a murine model Furthermore, we have identified several transcription factors that are candidate mediators of this effect. These data strongly support a role for IL-6 in the progression of prostate cancer to an androgen-independent tumor and provide potential molecular therapeutic targets.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418080
Entities
People
- Evan T Keller
Organizations
- University of Michigan