Cadherin-11 and Breast Cancer
Abstract
Cadherin-11 is unique amongst cadherins in that it is exists as two alternatively spliced forms that are expressed together in the same cell. In year 1 of this grant we showed that the presence of the cadherin-11 splice variant promotes invasion of cadherin-11 positive breast cancer cells, perhaps by promoting cell-ECM interactions. In year two of the grant we have tested the hypothesis that inhibition of cadherin-11 function using proprietary small molecule cadherin-11 inhibitors influences the ability of cadherin-11-expressing cells to invade in vitro. Our data show that a particular class of inhibitors designed to block the ability of cadherin-11 to interact with the extracellular matrix does indeed inhibit cell invasion. Other molecules designed to disrupt the cell-cell adhesive function of cadherin-11 did not affect cell invasion. In other studies we have generated cell lines expressing siRNA directed at both cadherin-11 and cadherin-11 variant.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA418106
Entities
People
- Stephen W. Byers
Organizations
- Georgetown University