Miniaturized DNA Biosensor for Decentralized Breast-Cancer Screening

Abstract

The use of DNA testing as an important component of breast cancer diagnosis has been increasing rapidly over the past decade. The goal of this project is to develop and characterize an electrochemical biosensing microsystem for the rapid point-of-care genetic screening of breast-cancer. During the third year of this project we introduced new electrical routes for further improving the performance of DNA biosensors for genetic screening of breast-cancer. Particular attention has been given to simultaneous measurements of several breast-cancer related sequences and to the signal amplification in connection to several nanoparticle tracers and highly sensitive stripping voltammetric detection of the metal tag. Additional developmental work, aimed at transforming these powerful nanoparticle-based bioassays to a miniaturized flow system, is in progress towards the realization of wide-scale decentralized screening for breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA418130

Entities

People

  • Joseph Wang

Organizations

  • New Mexico State University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Bioassay
  • Biochemistry
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Detectors
  • Genetic Testing
  • Hydroxides
  • Materials
  • Materials Laboratories
  • Materials Processing
  • Materials Science
  • Metallic Nanoparticles
  • Nanoparticles

Readers

  • Integrated Circuit Design and Technology.
  • Nanocomposite Materials Science
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology