The Roles of the Y Chromosome Genes in Prostate Cancer
Abstract
Currently we lack information on the role of the men-only chromosome, the Y chromosome, on prostate cancer. This project is designed to address this problem and to identify candidate genes on the Y chromosome involved in this male-specific cancer. The objectives are: 1) to study the expression of Y chromosome genes in prostate cancer and, 2) to evaluate their effects in over-expression in the prostate of transgenic mice. We have completed a survey on the expression of 31 Y chromosome genes in prostate cancer and have identified TSPY gene to be the most likely one to play a role in male oncogenesis. We have isolated and sequenced several polymorphic TSPY transcripts in normal and cancerous prostate samples, demonstrated that over-expression of TSPY potentiates cell proliferation in vitro and tumor formation in vivo. TSPY interacts with the mitotic cyclin B. Its expression is influenced by androgen. For the no-cost extension period, we hope to finish our transgenic study in over-expressing this and other Y chromosome gene(s) in prostates of mice and to evaluate its effects in prostatic oncogenesis and to define the TSPY domain(s) important for its interaction with the mitotic cylin B. These studies will provide important information on the role of this male-specific chromosome on prostate cancer development and treatments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2003
- Accession Number
- ADA418194
Entities
People
- Yun-fai C. Lau
Organizations
- Northern California Institute for Research and Education