The Role of PRIP in Breast Cancer
Abstract
Estrogen plays an important role in the normal breast and breast cancer development. Estrogens exert their cellular effects through ER that is a member of nuclear receptor superfamily. PRIP(Peroxisome proliferator receptor interacting protein) is a nuclear receptor coactivator that is amplified and overexpressed in breast cancer. The proposal was to investigate how the PRIP dysregulation contributes to abnormal growth and neoplastic development of breast. During the second year of the award, we disrupted PRIP gene in mice by homologous recombination. Mice nullizygous for PRIP died between embryonic day 11.5 and 12.5 (post coitum), indicating that PRIP like PBP, CBP, and p300 is an essential and nonredundant coactivator. We have created heterozygous mice with conditional inactivated PRIP gene which will finally help to reveal the function of this important coactivator in mammary gland. We found that PRIP overexpression occurs in about 60% and gene amplification occurs 10% of the breast cancers, suggesting that this coactivator plays an important role in the breast cancer development.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA418213
Entities
People
- Janardan K. Reddy
- Sunil S. Badve
- Yijun Zhu
Organizations
- Northwestern University