Beam Delivery Verification for Modulated Electron Radiation Therapy Treatment of Breast Cancer
Abstract
Detecting and monitoring cellular and molecular changes associated with cancer are essential to the verification of cancer treatment. In this investigation we show that modulated electron radiation therapy can in principle conform a region of high dose to a volume of malignant breast tissue. Currently available means to both measure the malignant volume and record progression of its response to radiation are limited. We therefore chose to explore another means to determine the breast treatment target; optical tomography. Using the fact that mammalian tissues transmit light at a low level and emit virtually no light at all, optical signatures conferred on tumor cells by expression of reporter genes can be detected externally by photon-detecting systems. In this paper we study a first approach to a gradient-based iterative procedure using a finite-difference scheme as forward model. We provide results at the current state of research and discuss ways to address current limitations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA418355
Entities
People
- Arthur L. Boyer
- Maxime Ponineau
Organizations
- Stanford University